Search results for "Oleanolic acid glycosides"

showing 2 items of 2 documents

Cytotoxic glycosides from the roots of Weigela x “Bristol Ruby”

2019

International audience; Seven oleanane-type glycosides were extracted and isolated by various chromatographic methods from the roots of Weigela x "Bristol Ruby" (1-7), six previously undescribed (1-6) and a known one (7). Their structures were assigned by spectroscopic analysis mainly 2D NMR and mass spectrometry (ESIMS). Selected triterpenoid glycosides (1-3, 6, 7) displayed a good cytotoxic activity against a mouse colon cancer cell line CT26.

WeigelaCytotoxicityPhytochemicalsOleanolic acid glycosidesMass spectrometryPlant Roots01 natural sciencesCaprifoliaceaeMiceTriterpenoidCell Line TumorDrug Discovery[SDV.IDA]Life Sciences [q-bio]/Food engineeringAnimalsCytotoxic T cellGlycosidesOleanolic AcidCytotoxicityCaprifoliaceaePharmacologychemistry.chemical_classificationChromatographyMolecular Structurebiology010405 organic chemistryGlycosideGeneral MedicineWeigela x “Bristol Ruby”biology.organism_classificationAntineoplastic Agents PhytogenicTriterpenesNMR3. Good health0104 chemical sciences010404 medicinal & biomolecular chemistrychemistryTwo-dimensional nuclear magnetic resonance spectroscopy
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Phytochemistry of Weigela x "kosteriana variegata" (Caprifoliaceae)

2018

International audience; One new triterpene glycoside 3-O-beta-D-xylopyranosyl-(1 -> 4)-[beta-D-glucopyranosyl-(1 -> 3)]-beta-D-xyl opyranosyl-(1 -> 4)-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyloleanolic acid, was isolated from Weigela x "kosteriana variegata" (Caprifoliaceae), with three known ones. Their structures were characterized by a combination of mass spectrometry and 1D and 2D NMR spectrocopic techniques including H-1- and C-13 NMR, COSY, TOCSY, NOESY, HSQC, and HMBC experiments. The toxicological properties of some glycosides were determined with a zebrafish-based assay. The results show that the most active compounds were toxic to the …

[SDV.AEN] Life Sciences [q-bio]/Food and NutritionWeigela x "kosteriana variegata"[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/PharmacologyZebrafish-based assay[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/PharmacologyOleanolic acid glycosides2D NMR[SDV.AEN]Life Sciences [q-bio]/Food and NutritionCaprifoliaceae
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